Energy balance
Butyrate supplementation or increased endogenous production via resistant starch and fiber intake promotes weight management by increasing energy expenditure through AMPK activation and PGC-1α induction, and by reducing energy intake via GLP-1 and PYY secretion.
To leverage butyrate for weight management, focus on increasing your intake of resistant starch and dietary fibers rather than relying solely on supplements. Incorporate foods like cooked-and-cooled potatoes, legumes, and raw bananas into your diet. These substrates feed gut bacteria to produce butyrate, which may help regulate energy expenditure and satiety hormones like GLP-1 and PYY. A clinical trial used 4g of sodium butyrate daily, but dietary modification is the primary natural strategy discussed.
Butyrate supplementation was found to have multiple metabolic benefits, including prevention of high-fat diet (HFD)-induced obesity and obesity-associated disorders in the animal model... the mechanism of butyrate action for obesity is related to the activation of AMPK, increasing ATP consumption, and the induction of PGC-1α activity... oral administration of butyrate in mice induces satiety and reduces cumulative food intake... oral butyrate has the capacity to evoke an anorectic response increasing plasma levels of GLP-1... and PYY
Why this rating
The paper is a review citing preclinical animal models and a few small human trials; robust large-scale human RCTs are not the primary focus.
Source
The Protective Role of Butyrate against Obesity and Obesity-Related Diseases
Serena Coppola et al. · Molecules · 2021
DOI 10.3390/molecules26030682
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