Research
Adherence
Lifestyle modifications can improve insulin sensitivity and delay progression to type 2 diabetes, although quantitative evaluation of insulin sensitivity was often missing from early trials.
Lifestyle changes are effective at delaying type 2 diabetes in people with impaired glucose tolerance. While early trials didn't always measure insulin sensitivity directly, it is possible that these changes improve insulin sensitivity. Pharmacological options like metformin are also available.
GoodSupportsHIGH confidence
Several clinical trials have shown that lifestyle modification delays the progression to type 2 diabetes among individuals with impaired glucose tolerance... It is possible that an improvement in insulin sensitivity can be achieved either through lifestyle modification or pharmacologically with metformin or thiazolidinediones.
Why this rating
Supported by multiple clinical trials cited (references 14-17).
Source
Evaluation of Insulin Sensitivity in Clinical Practice and in Research Settings
Lais U. Monzillo et al. · Nutrition Reviews · 2003
DOI 10.1301/nr.2003.dec.397-412
narrative_reviewCited 258×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The hyperinsulinemic euglycemic clamp is the gold standard method for quantifying insulin sensitivity in vivo, offering high reproducibility and the ability to distinguish hepatic from peripheral resistance.Strong
- Insulin resistance is the core metabolic abnormality in type 2 diabetes and is directly related to the risk of developing atherosclerosis and cardiovascular disease.Good
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