Research
Macro partitioning
High intake of saturated fats and trans-fatty acids from red meat and processed foods promotes renal inflammation, oxidative stress, and lipid accumulation, contributing to CKD progression, while polyunsaturated fatty acids (PUFAs) may exert protective effects.
Reduce intake of saturated and trans-fats found in red meat and processed foods. Increase consumption of polyunsaturated fats, particularly n-3 PUFAs from fish, which are associated with a lower incidence of CKD.
GoodSupportsHIGH confidence
The adverse effects of dietary saturated fats on kidney function, however, are supported by several recent studies... saturated fats may promote the progression of diabetic nephropathy while PUFAs may exert protective effects.
Why this rating
Supported by multiple animal studies showing increased oxidative stress and inflammation with high-fat diets, and human studies linking saturated fat to hyperalbuminuria.
Source
The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease
Alex Odermatt · American Journal of Physiology-Renal Physiology · 2011
narrative_reviewCited 257×
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