Micronutrients & recovery
Gut microbiota composition and microbial metabolites, specifically Trimethylamine N-oxide (TMAO), directly contribute to the pathogenesis of metabolic syndrome by promoting insulin resistance and atherosclerosis.
Your gut bacteria turn certain nutrients (like those in red meat and eggs) into a compound called TMAO, which harms your heart and insulin sensitivity. You can mitigate this by improving your gut health through fiber-rich foods (prebiotics), fermented foods (probiotics), or discussing microbiome-targeted therapies with your doctor, rather than simply cutting out healthy foods.
TMAO promotes insulin resistance, promotes atherosclerosis by decreasing reverse cholesterol transport and increases forward cholesterol transport. TMAO has been shown to be proatherogenic in mice... clarifying the cardiovascular disease potential of TMAO.
Why this rating
Supported by metagenome-wide association studies, animal models, and human epidemiological data linking TMAO to disease.
Source
Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic
Donna L. Mendrick et al. · Toxicological Sciences · 2017
DOI 10.1093/toxsci/kfx233
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