Research
Mixed
Comprehensive longitudinal monitoring of aging factors—including physical, psychological, and nutritional variables—is necessary to identify early markers of disease and determine reference values for normal aging.
To optimize long-term health, do not rely on a single metric. Regularly assess your physical function, nutritional intake, and psychological well-being. This holistic approach helps distinguish normal aging from disease onset, allowing for earlier intervention.
StrongSupportsHIGH confidence
The main purpose of the study is the systematic observation and description of the process of aging in humans: (1) to quantify normal and successful aging as well as to clarify the occurrence and processes of geriatric diseases; (2) to determine reference values in the normal aging process by longitudinal observation.
Why this rating
Large-scale (2,400 participants), stratified random sample, longitudinal design with repeated measures.
Source
A New Comprehensive Study on Aging the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)
Hiroshi Shimokata et al. · Journal of Epidemiology · 2000
DOI 10.2188/jea.10.1sup_1
cohort · n=2400Cited 256×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →