Research
Energy balance
CD38 deficiency enhances energy expenditure and resting metabolic rate, independent of physical activity levels.
Even without exercising more, your body can burn more calories if your cellular machinery (mitochondria) is optimized. This study shows that removing CD38 boosts mitochondrial function and energy burning. This suggests that supporting mitochondrial health is key to weight management.
GoodSupportsHIGH confidence
CD38-deficient animals have a higher metabolic rate compared to control mice... calorimetric studies indicate that CD38-deficient animals have a higher metabolic rate.
Why this rating
Direct calorimetric measurements provide strong evidence for increased energy expenditure.
Source
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesity
Maria Thereza Barbosa et al. · The FASEB Journal · 2007
DOI 10.1096/fj.07-8290com
mechanism_onlyCited 252×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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