Energy balance
Dietary restriction (DR) and intermittent fasting (IF) extend lifespan and improve health markers in animal models and humans, with some evidence suggesting greater longevity benefits in females, though IF may be more feasible for women.
Dietary restriction and intermittent fasting can improve health and potentially extend lifespan, with some animal studies showing greater benefits for females. For women, intermittent fasting (e.g., eating normally on 5 days and restricting calories on 2 non-consecutive days) is a feasible way to reduce weight and improve insulin sensitivity without the extreme deprivation of continuous DR. Consult a healthcare provider before starting, especially if you have underlying health conditions.
genetic mutations inhibiting IIS and TOR nutrient sensing signalling have a stronger effects on lifespan extension in females... IF (two non-consecutive days per week over a 6-month period) is an effective intervention to reduce weight, fat mass and waist circumference as well as to improve insulin sensitivity
Why this rating
Strong evidence in animal models; moderate evidence in human trials for IF, but limited long-term human longevity data.
Source
Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine
Rita Ostan et al. · Clinical Science · 2016
DOI 10.1042/cs20160004
More from this paper
- Women live longer than men globally, but this survival advantage is offset by a higher prevalence of disability and age-related diseases in later life, resulting in similar healthy life expectancy between genders.Good
- Menopause significantly increases cardiovascular risk in women by altering lipid profiles and promoting central adiposity, which worsens coronary artery disease outcomes more than in men.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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