Research

Energy balance

Dietary restriction (DR) and intermittent fasting (IF) extend lifespan and improve health markers in animal models and humans, with some evidence suggesting greater longevity benefits in females, though IF may be more feasible for women.

Dietary restriction and intermittent fasting can improve health and potentially extend lifespan, with some animal studies showing greater benefits for females. For women, intermittent fasting (e.g., eating normally on 5 days and restricting calories on 2 non-consecutive days) is a feasible way to reduce weight and improve insulin sensitivity without the extreme deprivation of continuous DR. Consult a healthcare provider before starting, especially if you have underlying health conditions.

ModerateSupportsMEDIUM confidence
genetic mutations inhibiting IIS and TOR nutrient sensing signalling have a stronger effects on lifespan extension in females... IF (two non-consecutive days per week over a 6-month period) is an effective intervention to reduce weight, fat mass and waist circumference as well as to improve insulin sensitivity
Rita Ostan et al. · Clinical Science · 2016

Why this rating

Strong evidence in animal models; moderate evidence in human trials for IF, but limited long-term human longevity data.

Source

Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

Rita Ostan et al. · Clinical Science · 2016

DOI 10.1042/cs20160004

narrative_reviewCited 252×
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DOI resolved against Crossref · corpus check 2026-06-10

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