Mixed
Genetically predicted leisure television watching causally increases the risk of COVID-19 hospitalization and disease severity.
Reduce time spent watching television, as it is causally linked to higher risks of COVID-19 hospitalization and severity. This risk is mediated by metabolic factors like obesity and smoking, so replacing TV time with physical activity may mitigate these risks.
Genetically proxied leisure television watching was significantly associated with an increased risk of COVID-19 hospitalization (OR = 1.55, 95% CI 1.29–1.88; P = 4.68 × 10–6), and greater disease severity (OR = 1.85, 95% CI 1.33–2.56; P = 0.0002).
Why this rating
Large-scale MR design with robust sensitivity analyses (MR-Egger, MR-PRESSO) confirming the association despite heterogeneity.
Source
Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study
Xiong Chen et al. · Journal of Translational Medicine · 2022
DOI 10.1186/s12967-022-03407-6
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