Mixed
Centenarians exhibit a distinct gut microbiota profile characterized by increased diversity and enrichment of specific beneficial taxa (Akkermansia, Christensenellaceae, Bifidobacterium) alongside an increase in facultative anaerobes (Proteobacteria), which correlates with longevity and healthy aging.
While you cannot simply 'take' a centenarian microbiota, the research suggests that maintaining high microbial diversity and supporting beneficial taxa (like Akkermansia and Christensenellaceae) through a diverse, fiber-rich diet and healthy lifestyle may support the adaptive gut ecosystem associated with healthy aging.
In extreme longevity, this shrinkage is counterbalanced by an increase in longevity-adapted and possibly health-promoting subdominant species (e.g., Akkermansia, Bifidobacterium, Christensenellaceae) as well as in their co-occurrence network... In extremely aged people, centenarians and semi-supercentenarians, an overall increase has been observed in the GM diversity.
Why this rating
The paper is a review of observational studies and cross-sectional comparisons; no causal intervention is tested.
Source
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
Aurelia Santoro et al. · Cellular and Molecular Life Sciences · 2017
DOI 10.1007/s00018-017-2674-y
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →