Research
Mixed
Genetic risk for daytime sleepiness shares significant genetic overlap with psychiatric traits (neuroticism, depression, bipolar disorder) and coronary heart disease, independent of BMI.
Daytime sleepiness may be a marker for broader health risks, including heart disease and mental health conditions. Managing sleepiness might also be part of a broader strategy to mitigate these shared genetic risks.
GoodSupportsHIGH confidence
The genetic correlations with coronary artery disease and psychiatric traits persisted after adjusting for BMI.
Why this rating
Large scale LDSC analysis with multiple comparisons correction.
Source
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Heming Wang et al. · Nature Communications · 2019
DOI 10.1038/s41467-019-11456-7
cohort · n=452071Cited 251×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Genetic variants associated with excessive daytime sleepiness cluster into two distinct biological subtypes: 'sleep propensity' (linked to higher sleep efficiency and morning chronotype) and 'sleep fragmentation' (linked to lower sleep efficiency and insomnia symptoms).Good
- Higher Body Mass Index (BMI) has a putative causal effect on increased daytime sleepiness, as determined by Mendelian Randomization analysis.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →