Research

Micronutrients & recovery

Early nutritional intervention with zinc, selenium, and vitamin D in high-risk or exposed individuals may protect against severe COVID-19 progression by mitigating low-grade inflammation and supporting immune function.

If you are in a high-risk group (elderly, chronic conditions) or exposed to SARS-CoV-2, ensure your zinc, selenium, and vitamin D levels are adequate. Do not wait for severe symptoms. Start supplementation early, adhering to safe upper limits (Zn ≤25mg, Se 100-200µg, Vit D 40-100µg daily), as this may help mitigate severe inflammation. This is an adjuvant therapy, not a replacement for medical care.

LimitedConditionalLOW confidence
We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.
Jan Alexander et al. · Nutrients · 2020

Why this rating

The authors explicitly state direct evidence is 'observational and weak' and rely on extrapolation from other viral infections.

Source

Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19

Jan Alexander et al. · Nutrients · 2020

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