Hormonal
Gut-derived lipopolysaccharides (LPS) translocate across a dysfunctional intestinal barrier into the portal circulation, where they activate the TLR4 signaling pathway in liver cells, driving inflammation and fibrosis in NAFLD and ALD.
For individuals with fatty liver disease, the health of the gut barrier is directly linked to liver inflammation. Maintaining gut integrity through a balanced diet (like the Mediterranean diet) and potentially using targeted therapies (like probiotics or IAP) may help reduce liver damage by preventing harmful bacterial products (LPS) from entering the bloodstream and triggering liver inflammation.
Gut dysbiosis and gut barrier dysfunction both contribute to chronic liver disease by abnormal regulation of the gut-liver axis. Thereby, gut-derived lipopolysaccharides (LPS) are a key factor in inducing the inflammatory response of liver tissue. LPS plays an important role in conducting liver damage through the LPS-TLR4 signaling pathway.
Why this rating
The paper is a review citing multiple human and animal studies, establishing strong associative and mechanistic evidence, though direct causal intervention trials are noted as needing further investigation.
Source
The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases
Lingxuan An et al. · Journal of Gastrointestinal Surgery · 2021
DOI 10.1007/s11605-021-05188-7
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