Micronutrients & recovery
Intestinal Alkaline Phosphatase (IAP) supplementation can detoxify LPS, preserve gut barrier integrity, and attenuate liver fibrosis in NAFLD and ALD models.
Intestinal Alkaline Phosphatase (IAP) is a naturally occurring enzyme that helps detoxify harmful bacterial products in the gut. While promising in animal studies for reducing liver fibrosis and inflammation, it is not yet an approved treatment for humans. Focus on maintaining gut health through diet and potentially discussing targeted therapies with a healthcare provider.
IAP dephosphorylates substrates such as LPS and other pathogen-associated molecular patterns. Its role in reducing local intestinal inflammation and maintaining gut barrier function is reviewed later. Oral supplementation of IAP attenuated liver fibrosis in mice.
Why this rating
Evidence is strong in animal models and some human trials (Phase II), but it is not yet an approved standard therapy for chronic liver disease.
Source
The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases
Lingxuan An et al. · Journal of Gastrointestinal Surgery · 2021
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