Mixed
In cognitively normal elderly individuals, higher severity of obstructive sleep apnea (OSA) is associated with a faster longitudinal decrease in cerebrospinal fluid amyloid-beta 42 levels, indicating increased brain amyloid burden.
If you are over 55 and have symptoms of sleep apnea (loud snoring, gasping, daytime fatigue), getting diagnosed and treated (e.g., with CPAP) is not just about feeling rested; it may actively slow the buildup of Alzheimer's-related proteins in your brain. Prioritize sleep health as a neuroprotective strategy.
We found that severity of OSA indices (AHIall... and AHI4%...) were associated with annual rate of change of cerebrospinal fluid amyloid b42... In a sample of cognitively normal elderly, OSA was associated with markers of increased amyloid burden over the 2-year follow-up.
Why this rating
Longitudinal prospective study with standardized biomarkers (CSF and PET), though sample size for PET was small.
Source
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study
Ram A. Sharma et al. · American Journal of Respiratory and Critical Care Medicine · 2017
DOI 10.1164/rccm.201704-0704oc
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