Research
Hormonal
Leptin, secreted by adipose tissue, signals long-term energy stores to the brain, inhibiting NPY/AgRP neurons and activating POMC neurons to reduce food intake, with levels proportional to body fat.
Leptin is a hormone from fat cells that tells your brain about long-term energy stores. Higher body fat means higher leptin. It works by suppressing hunger neurons (NPY/AgRP) and activating satiety neurons (POMC) in the brain.
GoodSupportsHIGH confidence
Other circulating factors such as insulin and leptin relay information regarding long-term energy stores. Both hormones circulate at proportional levels to body fat content... and reduce food intake.
Why this rating
Review article citing multiple studies on leptin's effects.
Source
Peptides and Food Intake
Carmen Sobrino Crespo et al. · Frontiers in Endocrinology · 2014
DOI 10.3389/fendo.2014.00058
narrative_reviewCited 247×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Ghrelin is the only known orexigenic peptide hormone, stimulating food intake by activating NPY/AgRP neurons in the arcuate nucleus and inhibiting POMC neurons, with levels inversely correlated with body fat and meal status.Good
- Anorexigenic gut hormones (GLP-1, PYY, CCK, PP, OXM) are released post-prandially in proportion to caloric intake and inhibit appetite via central (ARC) and peripheral (vagal) pathways.Good
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