Energy balance
Losing obesity (achieving non-obesity status) after having been obese in young adulthood normalizes the risk of MASLD, at-risk MASH, and increased liver stiffness to levels comparable to those who were never obese.
If you were obese in your young adulthood but have since lost the weight to a non-obese range, your risk for serious liver conditions (like MASH and fibrosis) is likely the same as someone who was never obese. You do not need to worry about 'permanent' liver damage from your past obesity if you have achieved and maintained a healthy weight.
Losing obesity resulted in normalisation of odds for MASLD, at-risk MASH and increased LSM. These findings underline the importance of preventing and treating young adulthood obesity to maintain liver health.
Why this rating
Large retrospective cohort (NHANES, n=4,580) with robust sensitivity analyses, though reliance on self-reported historical weight introduces recall bias.
Source
<scp>MASLD</scp> , At‐Risk <scp>MASH</scp> and Increased Liver Stiffness Are Associated With Young Adulthood Obesity Without Residual Risk After Losing Obesity
Laurens A. van Kleef et al. · Liver International · 2024
DOI 10.1111/liv.16169
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