Hormonal
The presence of muricholic acids (MCAs) in mice is critical for their high basal bile acid and cholesterol synthesis and low serum LDL levels; genetic elimination of MCAs in mice results in a human-like metabolic phenotype characterized by reduced synthesis and increased LDL cholesterol.
This research highlights that mice and humans regulate cholesterol and bile acids differently due to specific bile acid types (MCAs). For humans, this implies that therapies targeting bile acid metabolism must account for species-specific pathways, as mouse models lacking these pathways (KO mice) better mimic human metabolic responses.
In conclusion, the presence of MCAs is critical for many of the known metabolic differences between mice and humans. The Cyp2c70-KO mouse should be useful in studies exploring potential therapeutic targets for human disease.
Why this rating
High-quality animal model study with clear genetic manipulation (CRISPR/Cas9) and robust biochemical measurements.
Source
Metabolism of mice and men
Kevin D. Hall · Current Opinion in Clinical Nutrition & Metabolic Care · 2012
DOI 10.1097/mco.0b013e3283561150
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →