Research
Hormonal
Bile duct ligation (BDL) paradoxically stimulates bile acid synthesis in wild-type mice but not in mice lacking MCAs, indicating that MCAs are required for this paradoxical response.
This finding suggests that the body's response to bile flow obstruction (cholestasis) is heavily influenced by the type of bile acids present. In humans, where MCAs are not produced, this paradoxical response does not occur, highlighting a key difference in how we might treat cholestatic diseases compared to rodent models.
GoodSupportsHIGH confidence
The doubling of bile acid synthesis following BDL in WT animals was abolished in KO mice, despite extinguished intestinal fibroblast growth factor (Fgf) expression in both groups.
Why this rating
Robust experimental design comparing WT and KO mice under BDL conditions.
Source
Metabolism of mice and men
Kevin D. Hall · Current Opinion in Clinical Nutrition & Metabolic Care · 2012
DOI 10.1097/mco.0b013e3283561150
mechanism_onlyCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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