Energy balance
Sibutramine treatment (10-15 mg/day) for 1 year in obese patients with type 2 diabetes significantly improves glycemic control (HbA1c) and metabolic parameters (lipids, blood pressure) primarily through weight loss, independent of the drug's direct pharmacological effects.
If you are obese and have type 2 diabetes, adding sibutramine (10-15 mg daily) to a calorie-reduced diet and behavioral counseling can significantly lower your HbA1c and improve your lipid profile and blood pressure over a year. This benefit is largely due to the weight loss achieved, not just the drug's direct action. Consult your doctor to see if this is appropriate for you.
Sibutramine treatment (10-15 mg/day) for 1 year in obese patients with type 2 diabetes significantly improves glycemic control (HbA1c) and metabolic parameters (lipids, blood pressure) primarily through weight loss, independent of the drug's direct pharmacological effects.
Why this rating
Randomized, double-blind, placebo-controlled trial with a substantial sample size (n=233) and a long duration (1 year).
Source
Weight loss with sibutramine improves glycaemic control and other metabolic parameters in obese patients with type 2 diabetes mellitus
Ken Fujioka et al. · Diabetes Obesity and Metabolism · 2000
DOI 10.1046/j.1463-1326.2000.00081.x
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