Research
Hormonal
Exercise training improves endothelial function and nitric oxide (NO) bioavailability by upregulating eNOS activity through shear stress mechanisms, thereby reducing peripheral resistance and improving vascular perfusion.
Regular aerobic exercise helps keep your blood vessels flexible and healthy by increasing nitric oxide production, which helps regulate blood pressure and blood flow.
GoodSupportsHIGH confidence
One of the most important molecular consequences of regular physical exercise is the absolute increase of vascular nitric oxide (NO) concentration. NO is responsible for vasodilation, which results in the lowering of peripheral resistance and increase of perfusion.
Why this rating
Supported by cell culture, animal, and human studies cited in the review.
Source
Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives
Gerhard Schüler et al. · European Heart Journal · 2013
DOI 10.1093/eurheartj/eht111
narrative_reviewCited 244×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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