Research
Adherence
Low patient compliance with exercise training programs is a major drawback limiting the effectiveness of exercise as a therapeutic intervention for cardiovascular disease prevention at the population level.
Sticking to an exercise routine is hard, especially when doing it alone at home. To succeed, seek supervised programs, join community groups, or start with very small, manageable goals to build habit.
StrongRefutesHIGH confidence
Unfortunately, the low compliance rate of the patients is the major drawback of the intervention exercise training (ET).
Why this rating
Based on the authors' critical assessment and cited trials showing dropping compliance rates.
Source
Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives
Gerhard Schüler et al. · European Heart Journal · 2013
DOI 10.1093/eurheartj/eht111
narrative_reviewCited 244×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Regular exercise training significantly reduces the risk of cardiovascular disease mortality and all-cause mortality in both primary and secondary prevention contexts, with benefits observed even at low doses (e.g., 15 minutes/day).Good
- Exercise training improves endothelial function and nitric oxide (NO) bioavailability by upregulating eNOS activity through shear stress mechanisms, thereby reducing peripheral resistance and improving vascular perfusion.Good
- Exercise training mobilizes endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) from the bone marrow, promoting vascular regeneration and endothelial repair.Good
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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