Research
Hormonal
DNA methylation at the CD38 locus is positively associated with BMI and waist circumference, potentially linking immune function (CD38 expression) to metabolic traits.
This finding suggests a link between immune system activity (specifically CD38) and body weight. While you cannot directly target this methylation site, maintaining immune health through anti-inflammatory diets and regular activity may support healthy metabolic function.
ModerateSupportsMEDIUM confidence
In our study, we observed a positive relationship between CD38 methylation and adiposity traits.
Why this rating
Replicated in ARIC and FHS case-control, but not FHS random sample; mechanism is inferred from bioinformatics and knockout mouse studies.
Source
Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference
Stella Aslibekyan et al. · Obesity · 2015
DOI 10.1002/oby.21111
cross_sectional · n=991Cited 243×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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