Research
Hormonal
DNA methylation at the PHGDH locus is associated with BMI, potentially linking serine biosynthesis pathways to obesity.
This research identifies a link between the serine biosynthesis pathway (PHGDH) and body weight. While not yet a target for intervention, it highlights the importance of balanced nutrition in supporting metabolic enzyme function.
ModerateQualifiesMEDIUM confidence
We identified associations between the methylation status of a CpG locus in PHGDH and BMI in samples from GOLDN, FHS, and borderline significant in ARIC.
Why this rating
Replicated in GOLDN and FHS, but only borderline significant in ARIC; mechanism is inferred from enzyme function.
Source
Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference
Stella Aslibekyan et al. · Obesity · 2015
DOI 10.1002/oby.21111
cross_sectional · n=991Cited 243×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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