Research
Mixed
Physical inactivity and high fat diet interact to promote obesity, particularly in genetically susceptible individuals, by limiting fat oxidation capacity.
If you have a family history of obesity, avoid being sedentary and limit dietary fat to 20-25% of energy. This combination helps overcome genetic tendencies for low fat oxidation and prevents weight gain.
GoodSupportsHIGH confidence
Furthermore, interaction between dietary fat and physical fitness determine fat balance, so that the obesity promoting effect of a high fat diet is enhanced in susceptible subjects, particularly in sedentary individuals with a genetic predisposition to obesity.
Why this rating
Supported by cross-sectional, longitudinal, and mechanistic studies cited.
Source
Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity
Arne Astrup · Public Health Nutrition · 2001
DOI 10.1079/phn2001136
narrative_reviewCited 242×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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