Mixed
A greater reduction in intrahepatic fat content (IFC) following a 6-month lifestyle intervention (Mediterranean diet and physical activity) is associated with improved oxidative stress and inflammatory status, specifically through increased catalase activity and reduced irisin and cytokeratin-18 levels, alongside better cardiorespiratory fitness.
For NAFLD patients, achieving a significant reduction in liver fat through a 6-month lifestyle program involving a calorie-restricted Mediterranean diet and regular physical activity (either high steps or interval training) leads to better oxidative stress and inflammatory profiles. Focus on adherence to the diet and increasing activity levels to maximize liver fat loss.
The present data show that the reduction of IFC is associated with an improvement in pro/antioxidant and pro-inflammatory status and a better cardiorespiratory fitness in NAFLD patients.
Why this rating
Randomized controlled trial with n=60, clear inclusion criteria, and objective MRI measurements, though limited by sample size.
Source
A Greater Improvement of Intrahepatic Fat Contents after 6 Months of Lifestyle Intervention Is Related to a Better Oxidative Stress and Inflammatory Status in Non-Alcoholic Fatty Liver Disease
Margalida Monserrat-Mesquida et al. · Antioxidants · 2022
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