Research
Hormonal
Sleep is an actively generated state by the central nervous system, regulated by homeostatic and circadian processes, rather than a passive loss of wakefulness.
Understand that sleep is an active biological process. Disrupting this active process (e.g., through poor sleep hygiene or disorders) has significant consequences because the brain is actively working to regulate states.
StrongSupportsVERY_HIGH confidence
Sleep is not merely the passive loss of wakefulness. Sleep states are actively generated by the central nervous system (CNS). Sleep is homeostatically regulated and temporally organized into distinct phases.
Why this rating
Based on 40 years of research and multiple preclinical/clinical studies cited.
Source
Sleep, Anesthesiology, and the Neurobiology of Arousal State Control
Ralph Lydic et al. · Anesthesiology · 2005
DOI 10.1097/00000542-200512000-00024
narrative_reviewCited 240×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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