Research
Hormonal
Pontine cholinergic neurotransmission is a causal factor in generating the activated brain state of REM sleep, including motor atonia.
This is a basic science finding. It explains the neurobiology of REM sleep but does not directly translate to a specific intervention for the general public.
GoodSupportsHIGH confidence
These data demonstrate that pontine cholinergic neurotransmission participates in generating the activated brain state of REM sleep.
Why this rating
Based on extensive preclinical animal studies (cats, mice) and some human data.
Source
Sleep, Anesthesiology, and the Neurobiology of Arousal State Control
Ralph Lydic et al. · Anesthesiology · 2005
DOI 10.1097/00000542-200512000-00024
narrative_reviewCited 240×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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