Research
Micronutrients & recovery
Folate supplementation reduces the risk of neoplasia and DNA damage in patients with long-standing ulcerative colitis.
If you have long-standing ulcerative colitis, ask your doctor to check your folate levels. Supplementation (often 5mg) may protect against colon cancer and blood clots by fixing DNA damage, especially if you take sulfasalazine.
ModerateSupportsMEDIUM confidence
Two case–control studies and a retrospective analysis have shown a protective effect of folate supplementation against dysplasia and cancer in patients with long-standing ulcerative colitis... 5 mg of daily folate was associated with an increase in the extent of genomic DNA methylation and a decrease in the extent of p53 strand breaks.
Why this rating
Based on case-control and retrospective studies; no placebo-controlled trials on cancer risk reduction exist.
Source
Nutrition and adult inflammatory bowel disease
J. Goh et al. · Alimentary Pharmacology & Therapeutics · 2003
DOI 10.1046/j.1365-2036.2003.01482.x
narrative_reviewCited 237×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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