Research
Mixed
Omega-3 LC-PUFA supplementation significantly reduces inflammatory biomarkers (such as CRP, IL-6, and TNF-alpha) in patients with chronic diseases (e.g., cardiovascular disease, renal disease, diabetes) and acute conditions (e.g., sepsis, pancreatitis), but generally has no significant effect on inflammatory biomarkers in healthy individuals.
If you have a chronic inflammatory condition, omega-3 supplementation may help lower inflammatory markers. If you are healthy, you likely will not see a significant anti-inflammatory benefit from omega-3s, as your baseline inflammation is already low.
GoodQualifiesHIGH confidence
Dietary omega-3 fatty acids are associated with plasma biomarker levels, reflecting lower levels of inflammation and endothelial activation in cardiovascular disease and other chronic and acute diseases... However, further research is required before definitive recommendations can be made about the routine use of omega-3 fatty acids in critically ill patients or with neurodegenerative or chronic renal disease.
Why this rating
Systematic review of 26 RCTs, though heterogeneity in doses and populations exists.
Source
Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials
Óscar Daniel Rangel-Huerta et al. · British Journal Of Nutrition · 2012
DOI 10.1017/s0007114512001559
systematic_reviewCited 237×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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