Research
Hormonal
Trans-resveratrol stimulates glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK), independent of the PI-3 kinase/Akt pathway.
This research suggests that resveratrol may help muscle cells take up more sugar by activating an energy-sensing enzyme (AMPK). While this is promising for metabolic health, it is based on cell studies, not human trials. Do not rely on this as a substitute for proven diabetes treatments.
ModerateSupportsMEDIUM confidence
t-RVT significantly induced glucose uptake in C2C12 cells, via AMPK activation, but not a phosphatidylinositol-3 kinase (PI-3 kinase) signal pathway.
Why this rating
The study is an in vitro experiment using a cell line (C2C12 myotubes), lacking human clinical data.
Source
Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
Chang-Eun Park et al. · Experimental & Molecular Medicine · 2007
DOI 10.1038/emm.2007.25
mechanism_onlyCited 237×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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