Energy balance
Genetic predisposition for higher leisure screen time (LST) and lower moderate-to-vigorous physical activity (MVPA) causally increases body mass index (BMI) and adiposity, and these protective effects of physical activity on disease risk are mediated or confounded by BMI.
This research suggests that the health benefits of reducing sedentary time and increasing physical activity are largely achieved through their effect on body weight and fat. To prevent diseases like type 2 diabetes and heart disease, managing body mass index is likely a key mechanism through which physical activity works.
multivariable MR analyses show that all protective causal effects of lower LST are either mediated or confounded by BMI.
Why this rating
Large sample size (up to 703,901 individuals) and robust Mendelian Randomization methods, though observational in nature.
Source
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Zhe Wang et al. · Nature Genetics · 2022
DOI 10.1038/s41588-022-01165-1
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