Mixed
Aging is driven by interconnected molecular mechanisms including DNA damage, telomere attrition, mitochondrial dysfunction, and NAD+ loss, which can be mitigated by interventions such as calorie restriction, improved sleep, and enhanced physical activity.
Focus on foundational lifestyle factors known to support cellular health: maintain a caloric balance (avoiding excess), prioritize sleep quality, and engage in regular physical activity. These behaviors target the molecular drivers of aging (DNA damage, mitochondrial function, NAD+ levels) identified in current research.
Emerging evidence suggests that aging is closely associated with telomere attrition, DNA damage, mitochondrial dysfunction, loss of nicotinamide adenine dinucleotide levels, impaired macro-autophagy, stem cell exhaustion, inflammation, loss of protein balance, deregulated nutrient sensing, altered intercellular communication, and dysbiosis. These age-related changes may be alleviated by intervention strategies, such as calorie restriction, improved sleep quality, enhanced physical activity, and targeted longevity genes.
Why this rating
This is a review paper summarizing extensive animal and clinical experiments, citing numerous studies, but lacking a single primary clinical trial.
Source
Molecular mechanisms of aging and anti-aging strategies
Yumeng Li et al. · Cell Communication and Signaling · 2024
DOI 10.1186/s12964-024-01663-1
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