Research
Hormonal
Thyroid hormone (T3) regulates skeletal muscle myogenesis by controlling intracellular T3 levels via D2 and D3 deiodinases, which determines satellite cell proliferation and differentiation.
Proper thyroid function is necessary for effective muscle repair and regeneration after injury or exercise. If you have thyroid issues, addressing them may improve your body's ability to repair muscle tissue.
GoodSupportsHIGH confidence
The balance between D2 and D3 expression determines TH intracellular levels and thus influences the proliferation and differentiation of satellite cells... D3 is highly expressed in activated and proliferating SCs; however, it is downregulated during the differentiation process... An increase in intracellular T3 levels is important to myocyte terminal differentiation...
Why this rating
Supported by mouse models (D2KO, D3 ablation) and cell culture studies.
Source
Role of thyroid hormone in skeletal muscle physiology
Flávia Fonseca Bloise et al. · Journal of Endocrinology · 2017
DOI 10.1530/joe-16-0611
narrative_reviewCited 231×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Thyroid hormone (T3) accelerates skeletal muscle contraction and relaxation rates by stimulating the expression of fast myosin heavy chain isoforms (MYH2, MYH1, MYH4) and sarcoplasmic reticulum Ca2+ ATPase (SERCA1a).Good
- Thyroid hormone (T3) increases skeletal muscle mitochondrial biogenesis, oxidative capacity, and resting metabolic rate by upregulating PGC1α, UCP3, and mitochondrial enzymes.Good
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