Research
Energy balance
Thyroid hormone (T3) increases skeletal muscle mitochondrial biogenesis, oxidative capacity, and resting metabolic rate by upregulating PGC1α, UCP3, and mitochondrial enzymes.
Normal thyroid function is essential for healthy muscle metabolism and energy production. If you have hypothyroidism, treatment can restore mitochondrial function and energy levels. Do not attempt to increase thyroid levels beyond normal ranges for metabolic boosting, as this can lead to muscle wasting and other health issues.
GoodSupportsHIGH confidence
TH stimulates oxidative pathways by increasing mitochondrial biogenesis... T3 positively regulated PGC1A... TH-induced mitochondrial biogenesis and activity are dependent on T3-induced autophagy... T3 also increases the expression of citrate synthase... and stimulates glycerol-3-phosphate dehydrogenase... T3 increases the expression of cytochrome c oxidase 1 and 4.
Why this rating
Supported by human trials (Barbe et al.) and mouse models.
Source
Role of thyroid hormone in skeletal muscle physiology
Flávia Fonseca Bloise et al. · Journal of Endocrinology · 2017
DOI 10.1530/joe-16-0611
narrative_reviewCited 231×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Thyroid hormone (T3) accelerates skeletal muscle contraction and relaxation rates by stimulating the expression of fast myosin heavy chain isoforms (MYH2, MYH1, MYH4) and sarcoplasmic reticulum Ca2+ ATPase (SERCA1a).Good
- Thyroid hormone (T3) regulates skeletal muscle myogenesis by controlling intracellular T3 levels via D2 and D3 deiodinases, which determines satellite cell proliferation and differentiation.Good
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