Research
Micronutrients & recovery
LSD1's ability to repress energy-expenditure genes is strictly dependent on cellular FAD (flavin adenine dinucleotide) levels, linking nutritional status to epigenetic control.
The enzyme LSD1, which suppresses fat-burning genes, requires FAD to work. If cellular FAD levels are low, LSD1 cannot repress these genes, leading to increased energy expenditure. This suggests that maintaining adequate levels of riboflavin (Vitamin B2), a precursor to FAD, may support healthy epigenetic regulation of metabolism.
GoodConditionalHIGH confidence
Our data suggest a novel mechanism where LSD1 regulates cellular energy balance through coupling with cellular FAD biosynthesis.
Why this rating
Strong mechanistic evidence showing that impairing FAD synthesis mimics LSD1 inhibition.
Source
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
Shinjiro Hino et al. · Nature Communications · 2012
mechanism_onlyCited 231×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →