Micronutrients & recovery
Maintaining circulating 25-hydroxyvitamin D (25(OH)D) levels between 75 and 100 nmol/L is associated with a statistically significant reduction in colorectal cancer risk compared to levels considered sufficient for bone health (50-62.5 nmol/L).
If you are concerned about colorectal cancer risk, aim for a circulating 25(OH)D level between 75 and 100 nmol/L. This range is associated with a 19-27% lower risk compared to the standard 'sufficiency' range (50-62.5 nmol/L) used for bone health. Note that levels above 100 nmol/L did not show further risk reduction. Women showed a statistically significant benefit, while men showed a non-significant inverse trend. Consult a healthcare provider to test your levels and determine if supplementation is appropriate for you.
Circulating 25(OH)D concentrations of 75–<87.5 and 87.5–<100 nmol/L, ranges considered beyond sufficiency, were associated with statistically significant 19% (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risks of colorectal cancer, respectively.
Why this rating
Large sample size (n=12,813), international pooling, and rigorous calibration of assays provide high confidence in the association, though observational design limits causal inference.
Source
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
Marjorie L. McCullough et al. · JNCI Journal of the National Cancer Institute · 2018
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