Hormonal
Th17 cells promote liver inflammation, fibrosis, and insulin resistance in NAFLD and obesity, primarily through IL-17 secretion which stimulates pro-inflammatory cytokine release and hepatic stellate cell activation.
High levels of Th17 cells and IL-17 are associated with worse insulin resistance and liver fibrosis in obesity and NAFLD. Reducing systemic inflammation through weight loss and metabolic control may lower Th17 activity, thereby improving insulin sensitivity and slowing liver disease progression.
Th1, Th17, and Tc cells have an aggravating effect... Th17 and Tc cells seem to induce more liver damage and fibrosis progression... IL-17 reduces hepatic, muscle and adipose tissue insulin sensitivity... Th17 cells have a clear fibrogenic effect
Why this rating
Strong support from animal models and human observational studies showing increased Th17 in disease states and functional data linking IL-17 to insulin resistance.
Source
The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity
Mikhaïl A. Van Herck et al. · Frontiers in Immunology · 2019
DOI 10.3389/fimmu.2019.00082
More from this paper
- Regulatory T (Treg) cells exert an attenuating effect on insulin resistance and hepatic inflammation in NAFLD and obesity, primarily through the secretion of inhibitory cytokines IL-10 and TGF-beta and PPAR-gamma-dependent functionality.Good
- IL-22, produced by Th22 cells, has a beneficial effect on NAFLD by alleviating steatosis and reducing transaminase levels through STAT3-mediated mechanisms, although its role in obesity pathogenesis is complex and context-dependent.Moderate
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