Hormonal
Plasma proteome profiling can identify specific protein panels that correlate with insulin resistance (HOMA-IR) and BMI better than or equal to traditional markers like adiponectin, allowing for the identification of high metabolic burden subgroups.
Current clinical markers may not fully capture metabolic risk. Proteomic profiling can identify specific protein panels that correlate better with insulin resistance and BMI than traditional markers like adiponectin. This suggests that future diagnostic tools may use these panels to more accurately identify individuals with high metabolic burden and tailor interventions accordingly.
Remarkably, of all proteins in our dataset, the five proteins most significantly correlating with BMI were inflammation factors... Nearly 40 plasma proteins correlated significantly with HOMA-IR... remarkably nine plasma proteins were even more significant [than adiponectin].
Why this rating
High-quality proteomics data, strong correlations, but observational in nature regarding the markers.
Source
Proteomics reveals the effects of sustained weight loss on the human plasma proteome
Philipp E. Geyer et al. · Molecular Systems Biology · 2016
DOI 10.15252/msb.20167357
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