Energy balance
Sustained weight loss (8 weeks of 12% body weight loss followed by 1 year of maintenance) significantly reduces systemic inflammation and improves insulin resistance markers in obese individuals, with the majority of participants benefiting from these metabolic improvements.
For obese individuals, achieving a 12% body weight loss through a strict caloric deficit (800 kcal/day) for 8 weeks, followed by maintenance, leads to significant reductions in systemic inflammation and improved insulin resistance. This benefit is observed in nearly all participants, suggesting that sustained weight loss is a highly effective intervention for improving metabolic health markers, even if individual protein trajectories vary.
Nearly all study participants benefited from weight loss regarding a ten-protein inflammation panel defined from the proteomics data.
Why this rating
Large cohort (n=43-52), longitudinal design, high-quality proteomics, but observational/interventional without a control group of non-weight-losers.
Source
Proteomics reveals the effects of sustained weight loss on the human plasma proteome
Philipp E. Geyer et al. · Molecular Systems Biology · 2016
DOI 10.15252/msb.20167357
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