Hormonal
High-fat diets disrupt circadian clock gene expression and desynchronize peripheral clocks from the central pacemaker, leading to metabolic disorders such as obesity and insulin resistance, regardless of total caloric intake or obesity development.
Your internal biological clock is sensitive to what you eat, not just how much. High-fat diets can disrupt the timing of your metabolic genes, leading to insulin resistance and weight gain even without overeating. To support metabolic health, prioritize balanced nutrient intake and consider the timing of your meals, especially fat consumption, to align with your body's natural rhythms.
This indicates that the combination of a disruption in the molecular circadian clock and a hypercaloric diet is more detrimental to body weight homeostasis than either of these factors alone... The alterations rely on two mechanisms: first, the lack of proper BMAL1 and CLOCK chromatin recruitment at the level of target promoters of previously oscillating genes; and second, the genesis of novel rhythmicity of a great number of genes was found to rely on changes in the presence and pattern of oscillation and chromatin recruitment of PPARγ.
Why this rating
The paper is a review summarizing multiple animal studies (mostly rodents) and cell lines; human data is limited to epidemiological correlations.
Source
Impact of nutrients on circadian rhythmicity
Johanneke E. Oosterman et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2014
DOI 10.1152/ajpregu.00322.2014
More from this paper
- The timing of food intake, particularly for high-fat and high-sugar diets, is a critical determinant of metabolic health, with feeding during the inactive (light) period causing greater adverse effects than feeding during the active (dark) period.Moderate
- Glucose and insulin act as entraining signals for peripheral clocks, and disruptions in glucose/insulin signaling (e.g., insulin resistance) can alter circadian gene expression in the liver.Moderate
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