Research
Mixed
High-fat diets increase gut permeability to bacterial lipopolysaccharides (LPS), leading to systemic inflammation and metabolic syndrome symptoms.
High-fat diets can increase gut permeability, allowing bacterial toxins (LPS) into your bloodstream, which causes inflammation and metabolic issues. Adding fermentable fibers like oligofructose may help reduce this permeability and inflammation.
GoodSupportsHIGH confidence
Increased intestinal permeability for bacterial lipopolysaccharides (LPS) in response to the consumption of high-fat diets resulting in an elevated systemic LPS level and low-grade inflammation.
Why this rating
Supported by multiple animal and human studies cited in the review.
Source
Gut microbiota and energy balance: role in obesity
Michaël Blaut · Proceedings of The Nutrition Society · 2014
DOI 10.1017/s0029665114001700
narrative_reviewCited 229×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Fermentable dietary fiber (e.g., guar gum) increases body weight and fat mass in high-fat diet-fed mice compared to non-fermentable fiber (e.g., oat fiber) due to increased energy extraction via short-chain fatty acid (SCFA) production.Moderate
- Activation of Free Fatty Acid Receptors (FFAR2/FFAR3) by SCFAs increases satiety hormones (GLP-1, PYY) and insulin sensitivity, which may counteract the obesogenic effects of SCFA energy extraction.Moderate
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