Hormonal
Metabolic syndrome is associated with a systemic proinflammatory state and increased oxidative stress, characterized by elevated plasma levels of TNFα and IL-6, higher malondialdehyde (lipid peroxidation), and lower plasma superoxide dismutase (SOD) activity.
If you have metabolic syndrome, your body is in a state of chronic low-grade inflammation and oxidative stress. This isn't just 'bad luck'; it's a biological response to visceral fat and metabolic dysfunction. Recognizing this inflammatory state is the first step to understanding why managing weight, blood sugar, and blood pressure is critical for long-term health.
Plasma levels of malondialdehyde, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower.
Why this rating
Observational study with a reasonable sample size (n=160) and clear statistical significance, but lacks causal intervention data.
Source
Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State
Margalida Monserrat-Mesquida et al. · Antioxidants · 2020
DOI 10.3390/antiox9030236
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