Research
Energy balance
SGLT2 inhibition induces a fasting-like metabolic state characterized by increased fatty acid oxidation, ketogenesis, and reduced hepatic steatosis independently of FGF21.
SGLT2 inhibitors shift the body's fuel source to fat and ketones, mimicking a fasting state. This metabolic switch occurs even if the hormonal pathway for fat loss (FGF21) is blocked.
GoodSupportsHIGH confidence
Taken together, these data demonstrate that SGLT2 inhibition triggers a fasting-like transcriptional and metabolic paradigm but requires FGF21 for reduction in adiposity.
Why this rating
Consistent findings across transcriptomic, metabolomic, and knockout mouse studies.
Source
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
Soravis Osataphan et al. · JCI Insight · 2019
DOI 10.1172/jci.insight.123130
mechanism_onlyCited 228×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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