Mixed
Higher genetically predicted hand grip strength has a causal protective effect against fracture risk, but does not causally reduce all-cause mortality or cardiovascular disease risk.
Focus on building grip strength and overall muscle mass primarily to protect your bones and prevent fractures as you age, rather than expecting it to directly prevent heart disease or extend your life. Use resistance training to maintain functional capacity and reduce fall risk.
Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk... MR analyses showed no evidence for causality in the associations of grip strength with CVD or all-cause mortality
Why this rating
Large-scale GWAS (N=195,180) combined with robust Mendelian Randomization provides high-confidence genetic evidence for causality, though observational confounding in non-genetic studies remains a counter-argument.
Source
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
Sara M. Willems et al. · Nature Communications · 2017
DOI 10.1038/ncomms16015
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