Mixed
Dietary restriction extends lifespan in laboratory model species (yeast, nematodes, flies, rodents) by reducing both age-dependent and age-independent mortality rates, but this effect is significantly attenuated or absent in non-model species and males.
Dietary restriction can extend lifespan in model organisms, but the benefit is not universal. It appears stronger in females and specific lab-adapted species. For humans, the balance of protein to calories matters more than total calories alone. Do not assume lab results translate directly to wild-type human physiology without considering sex and genetic background.
Overall, DR significantly increased lifespan... DR has less effect in extending lifespan in males and also in non-model organisms... reduction in both age-dependent and age-independent mortality rates drives life extension by DR among the well-studied laboratory model species
Why this rating
Large-scale meta-analysis of 145 studies across 36 species with robust statistical controls.
Source
Comparative and meta‐analytic insights into life extension via dietary restriction
Shinichi Nakagawa et al. · Aging Cell · 2012
DOI 10.1111/j.1474-9726.2012.00798.x
Related findings · Mixed
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