Research
Hormonal
Circadian rhythm disruption is associated with increased morbidity risk for inflammatory diseases, including cardiovascular disease, cancer, and metabolic disease.
Maintaining a regular sleep-wake cycle is crucial for long-term health, as disrupting your circadian rhythm increases the risk of inflammatory diseases like heart disease and cancer.
GoodSupportsHIGH confidence
Circadian dysregulation is found for increased morbidity risk for inflammatory diseases including cardiovascular disease (Reutrakul and Knutson, 2015), cancer (Levi and Schibler, 2007), and metabolic disease (Arble et al., 2010).
Why this rating
Cited from multiple epidemiological and mechanistic studies.
Source
Neuroinflammation, Sleep, and Circadian Rhythms
Mark R. Zielinski et al. · Frontiers in Cellular and Infection Microbiology · 2022
DOI 10.3389/fcimb.2022.853096
narrative_reviewCited 227×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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