Energy balance
Isocaloric substitution of added sugars (sucrose or HFCS) for other carbohydrates does not increase risk factors for obesity, type 2 diabetes, or cardiovascular disease in adults.
If you consume added sugars within your daily calorie needs, replacing them with other carbohydrates (like starch) will not improve your metabolic health markers (weight, blood sugar, lipids) any more than keeping them would. The key is total energy balance, not the specific source of calories, unless you are consuming excessive amounts that lead to a caloric surplus.
singling out added sugars as unique culprits for metabolically based diseases such as obesity, diabetes and cardiovascular disease appears inconsistent with modern, high quality evidence and is very unlikely to yield health benefits.
Why this rating
Based on systematic reviews, meta-analyses, and RCTs, though some RCTs had short durations or confounding weight gain.
Source
Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding
James M. Rippe et al. · Nutrients · 2016
DOI 10.3390/nu8110697
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