Energy balance
Sustained caloric restriction of 25% below ad libitum intake over two years induces metabolic adaptation, specifically reducing resting metabolic rate and core body temperature, in nonobese humans.
To potentially slow aging markers, non-obese adults may attempt a sustained 25% reduction in daily calories. This requires significant behavioral support and monitoring to maintain, as it is a substantial deficit compared to normal eating habits.
The primary hypotheses is that CR results in metabolic adaptation as defined by (a) a reduction in RMR adjusted for changes in body composition and (b) a reduction in core body temperature.
Why this rating
This is a study protocol/design paper; results are not yet reported, so evidence is currently 'hypothesis' level based on animal data.
Source
Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy
James Rochon et al. · The Journals of Gerontology Series A · 2010
DOI 10.1093/gerona/glq168
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →