Research
Energy balance
Sprint training (ST) specifically elevates creatine kinase (CK) activity, whereas speed endurance training (SET) does not, suggesting that the rate of creatine phosphate (CP) utilization, rather than total CP depletion, drives CK adaptation.
If you want to increase your muscle's creatine kinase activity, focus on very short, maximal sprints (e.g., 6-second all-out efforts). Speed endurance intervals, while beneficial for other adaptations, do not appear to stimulate CK increases in the same way.
GoodSupportsHIGH confidence
In SET, muscle CK was not changed, whereas in ST, it was higher (P < 0.05) after, compared with before, the training period... it may be that it is a high rate of CP utilization rather than the total net utilization of CP that is important for the adaptation of CK to training.
Why this rating
Clear biochemical measurement with statistical significance.
Source
Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development
Magni Mohr et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2006
DOI 10.1152/ajpregu.00251.2006
rct · n=13Cited 226×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Speed endurance training (SET), characterized by high lactate and hydrogen ion accumulation, specifically upregulates the Na+/H+ exchanger isoform 1 (NHE1) and Na+/K+-ATPase beta2-subunit, whereas sprint training (ST) does not, suggesting that intracellular acidosis is a key stimulus for these specific ion transport adaptations.Good
- Speed endurance training (SET) improves intermittent recovery performance (Yo-Yo IR-2) significantly more than sprint training (ST), primarily through enhanced lactate clearance and potassium handling rather than just increased muscle mass or fiber type changes.Good
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