Mixed
Human skeletal muscle contains two distinct muscle stem cell (MuSC) subpopulations: a 'quiescent' population (MuSC1) characterized by high PAX7 and EGFR expression, and an 'early-activated' population (MuSC2) characterized by inflammatory markers (TNFRSF12/FN14, CCL2) and signs of dysfunction associated with aging and wasting diseases.
This research highlights that muscle stem cells are not all the same. In healthy, young muscle, most stem cells are 'quiescent' (resting) and express EGFR, which is crucial for proper repair. However, in aging or disease states, a subset of stem cells becomes 'early-activated' and expresses inflammatory markers (like TNFRSF12/FN14) associated with muscle wasting. For fitness, this implies that maintaining muscle health through resistance training may help preserve the healthy, quiescent pool and prevent the shift toward this dysfunctional, inflammatory state seen in aging.
These observations suggest that MuSC1 is comprised of quiescent MuSCs, and MuSC2 is comprised of an early-activated MuSCs... MuSC2 is enriched for multiple markers of inflammation including CCL2, CXCL1, IL32, and surface receptor TNFRSF12/FN14... TNFRSF12/FN14 has been implicated in various muscle wasting diseases.
Why this rating
High-quality single-cell transcriptomic data from 10 diverse human donors, though observational and not interventional.
Source
A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations
Andrea J. De Micheli et al. · Skeletal Muscle · 2020
DOI 10.1186/s13395-020-00236-3
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